41-Azido-41-deoxyrapamycin
نویسندگان
چکیده
The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å(3) solvent-accessible voids.
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012